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Dennis Kyle

Blurred image of the arch used as background for stylistic purposes.
Cellular Biology Department Head, Professor of Infectious Diseases and Cellular Biology, Director, Center for Tropical & Emerging Global Diseases, GRA Eminent Scholar Chair in Antiparasitic Drug Discovery

Research in the Kyle lab focuses on the discovery, development, and mechanism(s) of resistance to anti-parasitic drugs. At present we focus on malaria, the most important parasitic disease of man, and the spectrum of diseases caused by pathogenic free-living amoebae, perhaps the most neglected of all tropical parasitic diseases. The overarching objectives of our research is to develop new tools to prevent disease, to train a new generation of parasitologists, to foster multidisciplinary research on tropical diseases, and to implement our findings to reduce the burden of parasitic diseases in endemic countries.

New drugs are urgently needed to combat malaria, primarily due to the emergence of drug resistance to one or more drugs - a phenomenon known as multidrug resistance. In addition, new drugs are needed that target the dormant hypnozoite stage of vivax malaria that can persist in the liver for weeks to months to years before activating to cause relapsing malaria. With funding from the Bill and Melinda Gates Foundation we have developed a novel system that permits long term maintenance of primary hepatocyte physiology in vitro and have used this technology to develop the first 384 well high content imaging assay to discover anti-hypnozoite drugs.

Elucidating mechanism(s) of resistance and discovering new drug treatment regimens, combinations, or strategies to overcome resistance is a second major research focus. Our studies have demonstrated novel phenotypes that allow P. falciparum to become resistant to artemisinin drugs. In addition, we’ve shown that cryptic mitochondrial heteroplasmy is the mechanism underlying resistance to atovaquone and other drugs that target the mitochondria of P. falciparum.

The pathogenic free-living amoebae Naegleria fowleri and Acanthamoeba spp. cause a spectrum of diseases that have no good treatment options. Primary amoebic meningoencephalitis is an acute fulminating disease caused by N. fowleri and it is >98% fatal within 2 weeks of exposure amoebae in warm freshwater. Acanthamoeba spp cause granulomatous amoebic encephalitis, amoebic keratitis, and skin infections that are equally difficult to treat. The Kyle lab has developed new high throughput methods and assays to discover new drugs that act rapidly, are cidal, and can be combined with existing drugs used to treat these nearly incurable diseases.

Research Interests:

Drug discovery for malaria and brain-eating amoebae; antimalarial resistance mechanisms

Complete List of Published Work:

Publications (since 2017)


Argomaniz, M., Cooper, C., Cheng, W., Vivas, A., Maher, S., Kyle, D., & Joyner, C. (2023). Adaptation of the Plasmodium cynomolgi Berok DC line to continuous in vitro culture.


Maher, S. P., Bakowski, M. A., Vantaux, A., Flannery, E. L., Andolina, C., Gupta, M., . . . Kyle, D. E. (2023). A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites.. bioRxiv. doi:10.1101/2023.01.31.526483


MalariaGEN., Abdel Hamid, M. M., Abdelraheem, M. H., Acheampong, D. O., Ahouidi, A., Ali, M., . . . van der Pluijm, R. W. (2023). Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples.. Wellcome Open Res, 8, 22. doi:10.12688/wellcomeopenres.18681.1


Marques-da-Silva, C., Poudel, B., Baptista, R. P., Peissig, K., Hancox, L. S., Shiau, J. C., . . . Kurup, S. P. (2023). AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes.. Proc Natl Acad Sci U S A, 120(2), e2210181120. doi:10.1073/pnas.2210181120


Ward, K. E., Christensen, P., Racklyeft, A., Dhingra, S. K., Chua, A. C. Y., Remmert, C., . . . Bifani, P. (2022). Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine. JOURNAL OF INFECTIOUS DISEASES, 6 pages. doi:10.1093/infdis/jiac469


Bowers, C., Hancox, L., Peissig, K., Shiau, J. C. C., Vantaux, A., Witkowski, B., . . . Kurup, S. P. P. (2022). Cryopreservation of Plasmodium Sporozoites. PATHOGENS, 11(12), 13 pages. doi:10.3390/pathogens11121487


Botnar, A., Lawrence, G., Maher, S. P., Vantaux, A., Witkowski, B., Shiau, J. C., . . . Kyle, D. E. (2022). Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.. Int J Parasitol, 52(11), 733-744. doi:10.1016/j.ijpara.2022.03.003


Vantaux, A., Peneau, J., Cooper, C. A., Kyle, D. E., Witkowski, B., & Maher, S. P. (2022). Liver-stage fate determination in Plasmodium vivax parasites: Characterization of schizont growth and hypnozoite fating from patient isolates. FRONTIERS IN MICROBIOLOGY, 13, 13 pages. doi:10.3389/fmicb.2022.976606


Pathak, A. K., Shiau, J. C., Franke-Fayard, B., Shollenberger, L. M., Harn, D. A., Kyle, D. E., & Murdock, C. C. (2022). Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands. MALARIA JOURNAL, 21(1), 11 pages. doi:10.1186/s12936-022-04270-y


Limon, A. -C. D., Patabendige, H. M. L. W., Azhari, A., Sun, X., Kyle, D. E., Wilson, N. G., & Baker, B. J. (2022). Chemistry and Bioactivity of the Deep-Water Antarctic Octocoral Alcyonium sp.. MARINE DRUGS, 20(9), 12 pages. doi:10.3390/md20090576


Ruberto, A. A., Maher, S. P., Vantaux, A., Joyner, C. J., Bourke, C., Balan, B., . . . Kyle, D. E. (2022). Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 12, 23 pages. doi:10.3389/fcimb.2022.986314


Marques-da-Silva, C., Peissig, K., Walker, M. P., Shiau, J., Bowers, C., Kyle, D. E., . . . Kurup, S. P. (2022). Direct type I interferon signaling in hepatocytes controls malaria. CELL REPORTS, 40(3), 15 pages. doi:10.1016/j.celrep.2022.111098


Christensen, P., Racklyeft, A., Ward, K. E., Matheson, J., Suwanarusk, R., Chua, A. C. Y., . . . Russell, B. (2022). Improving in vitro continuous cultivation of Plasmodium cynomolgi, a model for P. vivax. PARASITOLOGY INTERNATIONAL, 89, 6 pages. doi:10.1016/j.parint.2022.102589


Cank, K. B., Shepherd, R. A., Knowles, S. L., Rangel-Grimaldo, M., Raja, H. A., Bunch, Z. L., . . . Oberlies, N. H. (2022). Polychlorinated cyclopentenes from a marine derived Periconia sp. (strain G1144). PHYTOCHEMISTRY, 199, 8 pages. doi:10.1016/j.phytochem.2022.113200


Dong, Y., Sonawane, Y., Maher, S. P., Zeeman, A. -M., Chaumeau, V., Vantaux, A., . . . Vennerstrom, J. L. (2022). Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12). ACS OMEGA, 7(14), 12401-12411. doi:10.1021/acsomega.2c01099


Iyamu, I. D., Zhao, Y., Parvatkar, P. T., Roberts, B. F., Casandra, D. R., Wojtas, L., . . . Manetsch, R. (2022). Structure-activity and structure-property relationship studies of spirocyclic chromanes with antimalarial activity.. Bioorg Med Chem, 57, 116629. doi:10.1016/j.bmc.2022.116629


Russell, A. C., & Kyle, D. E. (2022). Differential Growth Rates and In Vitro Drug Susceptibility to Currently Used Drugs for Multiple Isolates of Naegleria fowleri. MICROBIOLOGY SPECTRUM, 10(1), 12 pages. Retrieved from


Barney, R., Velasco, M., Cooper, C. A., Rashid, A., Kyle, D. E., Moon, R. W., . . . Jang, I. K. (2022). Diagnostic Characteristics of Lactate Dehydrogenase on a Multiplex Assay for Malaria Detection Including the Zoonotic Parasite Plasmodium knowlesi. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 106(1), 275-282. doi:10.4269/ajtmh.21-0532


Maher, S. P., Vantaux, A., Cooper, C. A., Chasen, N. M., Cheng, W. T., Joyner, C. J., . . . Kyle, D. (2021). A Phenotypic Screen for the Liver Stages of Plasmodium vivax.. Bio Protoc, 11(23), e4253. doi:10.21769/BioProtoc.4253


Phan, I. Q., Rice, C. A., Craig, J., Noorai, R. E., McDonald, J. R., Subramanian, S., . . . Myler, P. J. (2021). The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design. SCIENTIFIC REPORTS, 11(1), 13 pages. doi:10.1038/s41598-021-99903-8


Maher, S. P., Vantaux, A., Chaumeau, V., Chua, A. C. Y., Cooper, C. A., Andolina, C., . . . Kyle, D. E. (2021). Probing the distinct chemosensitivity of Plasmodium vivax liver stage parasites and demonstration of 8-aminoquinoline radical cure activity in vitro. SCIENTIFIC REPORTS, 11(1), 18 pages. doi:10.1038/s41598-021-99152-9


Lichorowic, C. L., Zhao, Y., Maher, S. P., Padin-Irizarry, V., Mendiola, V. C., de Castro, S. T., . . . Manetsch, R. (2021). Synthesis of Mono- and Bisperoxide-Bridged Artemisinin Dimers to Elucidate the Contribution of Dimerization to Antimalarial Activity. ACS INFECTIOUS DISEASES, 7(7), 2013-2024. doi:10.1021/acsinfecdis.1c00066


Troth, E., & Kyle, D. E. (2021). EdU Incorporation To Assess Cell Proliferation and Drug Susceptibility in Naegleria fowleri. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 65(7), 10 pages. doi:10.1128/AAC.00017-21


Sylvester, K., Maher, S. P., Posfai, D., Tran, M. K., Crawford, M. C., Vantaux, A., . . . Derbyshire, E. R. (2021). Characterization of the Tubovesicular Network in Plasmodium vivax Liver Stage Hypnozoites and Schizonts. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 11, 11 pages. doi:10.3389/fcimb.2021.687019


Monastyrskyi, A., Brockmeyer, F., LaCrue, A. N., Zhao, Y., Maher, S. P., Maignan, J. R., . . . Manetsch, R. (2021). Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1H)-Quinolones with Single Dose Cures. JOURNAL OF MEDICINAL CHEMISTRY, 64(10), 6581-6595. doi:10.1021/acs.jmedchem.0c01104


Tillery, L., Barrett, K., Goldstein, J., Lassner, J. W., Osterhout, B., Tran, N. L., . . . Van Voorhis, W. C. (2021). Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba. PLOS ONE, 16(3), 19 pages. doi:10.1371/journal.pone.0241738


Troth, E. V., & Kyle, D. E. (n.d.). EdU incorporation to assess cell proliferation and drug susceptibility for the brain-eating amoeba, <i>Naegleria fowleri</i>. doi:10.1101/2021.01.07.425827


McElroy, E. J., Nowak, B., Hill-Spanik, K. M., Granath, W. O., Connors, V. A., Driver, J., . . . de Buron, I. (2020). Dynamics of infection and pathology induced by the aporocotylid, Cardicola laruei, in Spotted Seatrout, Cynoscion nebulosus (Sciaenidae). INTERNATIONAL JOURNAL FOR PARASITOLOGY, 50(10-11), 809-823. doi:10.1016/j.ijpara.2020.03.016


Rice, C. A., Colon, B. L., Chen, E., Hull, M., & Kyle, D. E. (2020). Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae. PLOS NEGLECTED TROPICAL DISEASES, 14(9), 21 pages. doi:10.1371/journal.pntd.0008353


Posfai, D., Maher, S. P., Roesch, C., Vantaux, A., Sylvester, K., Peneau, J., . . . Derbyshire, E. R. (2020). Plasmodium vivax Liver and Blood Stages Recruit the Druggable Host Membrane Channel Aquaporin-3. CELL CHEMICAL BIOLOGY, 27(6), 719-+. doi:10.1016/j.chembiol.2020.03.009


Bory, A., Shilling, A. J., Allen, J., Azhari, A., Roth, A., Shaw, L. N., . . . Baker, B. J. (2020). Bioactivity of Spongian Diterpenoid Scaffolds from the Antarctic SpongeDendrilla antarctica. MARINE DRUGS, 18(6), 14 pages. doi:10.3390/md18060327


Rice, C. A., Troth, E., Russell, A. C., & Kyle, D. E. (2020). Discovery of Anti-Amoebic Inhibitors from Screening the MMV Pandemic Response Box on Balamuthia mandrillaris, Naegleria fowleri, and Acanthamoeba castellanii. PATHOGENS, 9(6), 17 pages. doi:10.3390/pathogens9060476


Shilling, A. J., Witowski, C. G., Maschek, J. A., Azhari, A., Vesely, B. A., Kyle, D. E., . . . Baker, B. J. (2020). Spongian Diterpenoids Derived from the Antarctic Sponge Dendrilla antarctica Are Potent Inhibitors of the Leishmania Parasite. JOURNAL OF NATURAL PRODUCTS, 83(5), 1553-1562. doi:10.1021/acs.jnatprod.0c00025


Rice, C. A., Troth, E. V., Russell, A. C., & Kyle, D. E. (n.d.). Discovery of anti-amoebic inhibitors from screening the MMV Pandemic Response Box on <i>Balamuthia mandrillaris, Naegleria fowleri</i> and <i>Acanthamoeba castellanii</i>. doi:10.1101/2020.05.14.096776


Rice, C. A., Colon, B. L., Chen, E., Hull, M. V., & Kyle, D. E. (n.d.). Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae. doi:10.1101/2020.05.13.093922


Rice, C. A., Fernando Lares-Jimenez, L., Lares-Villa, F., & Kyle, D. E. (2020). In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria and Pathogen Boxes To Discover Novel Compounds with Activity against Balamuthia mandrillaris. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 64(5), 6 pages. doi:10.1128/AAC.02233-19


Maher, S. P., Conway, A. J., Roth, A., Adapa, S. R., Cualing, P., Andolina, C., . . . Kyle, D. E. (2020). An adaptable soft-mold embossing process for fabricating optically-accessible, microfeature-based culture systems and application toward liver stage antimalarial compound testing. LAB ON A CHIP, 20(6), 1124-1139. doi:10.1039/c9lc00921c


Wong, H. N., Padin-Irizarry, V., van der Watt, M. E., Reader, J., Liebenberg, W., Wiesner, L., . . . Haynes, R. K. (2020). Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites. FRONTIERS IN CHEMISTRY, 7, 16 pages. doi:10.3389/fchem.2019.00901


Rivera, I., Linz, B., Dewan, K. K., Ma, L., Rice, C. A., Kyle, D. E., & Harvill, E. T. (2019). Conservation of Ancient Genetic Pathways for Intracellular Persistence Among Animal Pathogenic Bordetellae. FRONTIERS IN MICROBIOLOGY, 10, 13 pages. doi:10.3389/fmicb.2019.02839


Barrett, M. P., Kyle, D. E., Sibley, L. D., Radke, J. B., & Tarleton, R. L. (2019). Protozoan persister-like cells and drug treatment failure. NATURE REVIEWS MICROBIOLOGY, 17(10), 607-620. doi:10.1038/s41579-019-0238-x


Chua, A. C. Y., Ong, J. J. Y., Malleret, B., Suwanarusk, R., Kosaisavee, V., Zeeman, A. -M., . . . Bifani, P. (2019). Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages. NATURE COMMUNICATIONS, 10, 13 pages. doi:10.1038/s41467-019-11332-4


Baragana, B., Forte, B., Choi, R., Hewitt, S. N., Bueren-Calabuig, J. A., Pisco, J. P., . . . Gilbert, I. H. (2019). Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116(14), 7015-7020. doi:10.1073/pnas.1814685116


Colon, B. L., Rice, C. A., Guy, R. K., & Kyle, D. E. (2019). Phenotypic Screens Reveal Posaconazole as a Rapidly Acting Amebicidal Combination Partner for Treatment of Primary Amoebic Meningoencephalitis. JOURNAL OF INFECTIOUS DISEASES, 219(7), 1095-1103. doi:10.1093/infdis/jiy622


Antonova-Koch, Y., Meister, S., Abraham, M., Luth, M. R., Ottilie, S., Lukens, A. K., . . . Winzeler, E. A. (2018). Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. SCIENCE, 362(6419), 8 pages. doi:10.1126/science.aat9446


de Buron, I., Colon, B. L., Siegel, S. V., Oberstaller, J., Rivero, A., & Kyle, D. E. (2018). First evidence of polychaete intermediate hosts for Neospirorchis spp. marine turtle blood flukes (Trematoda: Spirorchiidae). INTERNATIONAL JOURNAL FOR PARASITOLOGY, 48(14), 1097-1106. doi:10.1016/j.ijpara.2018.08.002


Schafer, C., Dambrauskas, N., Steel, R. W., Carbonetti, S., Chuenchob, V., Flannery, E. L., . . . Sather, D. N. (2018). A recombinant antibody against Plasmodium vivax UIS4 for distinguishing replicating from dormant liver stages. MALARIA JOURNAL, 17, 10 pages. doi:10.1186/s12936-018-2519-7


Demers, D. H., Knestrick, M. A., Fleeman, R., Tawfik, R., Azhari, A., Souza, A., . . . Baker, B. J. (2018). Exploitation of Mangrove Endophytic Fungi for Infectious Disease Drug Discovery. MARINE DRUGS, 16(10), 11 pages. doi:10.3390/md16100376


Obaldia, N., Milhous, W. K., & Kyle, D. E. (2018). Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62(9), 7 pages. doi:10.1128/AAC.00582-18


Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum (vol 9, 2018). NATURE COMMUNICATIONS, 9, 1 page. doi:10.1038/s41467-018-04817-1


Roth, A., Maher, S. P., Conway, A. J., Ubalee, R., Chaumeau, V., Andolina, C., . . . Adams, J. H. (2018). A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum. NATURE COMMUNICATIONS, 9, 16 pages. doi:10.1038/s41467-018-04221-9


Siegel, S. V., Rivero, A. V., Oberstaller, J., Colon, B. L., de Buron, I., & Kyle, D. E. (2018). Blood flukes Cardicola parvus and C-laruei (Trematoda: Aporocotylidae): life cycles and cryptic infection in spotted seatrout, Cynoscion nebulosus (Teleost: Sciaenidae). PARASITOLOGY INTERNATIONAL, 67(2), 150-158. doi:10.1016/j.parint.2017.10.012


Duvalsaint, M., & Kyle, D. E. (2018). Phytohormones, Isoprenoids, and Role of the Apicoplast in Recovery from Dihydroartemisinin-Induced Dormancy of Plasmodium falciparum. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 62(3), 14 pages. doi:10.1128/AAC.01771-17


Antonova-Koch, Y., Meister, S., Abraham, M., Ottilie, S., Lukens, A., Sakata-Kato, T., . . . Winzeler, E. (2018). IDENTIFICATION OF A DUAL LIVER-ASEXUAL STAGE ANTIMALARIAL TARGETING PFDHODH. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 99 (pp. 535). New Orleans, LA: AMER SOC TROP MED & HYGIENE. Retrieved from


Thomas, S. A. L., von Salm, J. L., Clark, S., Ferlita, S., Nemani, P., Azhari, A., . . . Baker, B. J. (2018). Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima. JOURNAL OF NATURAL PRODUCTS, 81(1), 117-123. doi:10.1021/acs.jnatprod.7b00732


Neelarapu, R., Maignan, J. R., Lichorowic, C. L., Monastyrskyi, A., Mutka, T. S., LaCrue, A. N., . . . Manetsch, R. (2018). Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies. JOURNAL OF MEDICINAL CHEMISTRY, 61(4), 1450-1473. doi:10.1021/acs.jmedchem.7b00738


McQueen, A., Blake, L. D., Azhari, A., Kemp, M. T., McGaha, T. W., Namelikonda, N., . . . Kyle, D. E. (2017). Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27(20), 4597-4600. doi:10.1016/j.bmcl.2017.09.030


Siegel, S., Rivero, A., Adapa, S. R., Wang, C., Manetsch, R., Jiang, R. H. Y., & Kyle, D. E. (n.d.). Mitochondrial heteroplasmy is responsible for Atovaquone drug resistance in <i>Plasmodium falciparum</i>. doi:10.1101/232033


Kosaisavee, V., Suwanarusk, R., Chua, A. C. Y., Kyle, D. E., Malleret, B., Zhang, R., . . . Russell, B. (2017). Strict tropism for CD71(+)/CD234(+) human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi. BLOOD, 130(11), 1357-1363. doi:10.1182/blood-2017-02-764787


Kanwar, A., Eduful, B. J., Barbeto, L., Bonomo, P. C., Lemus, A., Vesely, B. A., . . . Leahy, J. W. (2017). Synthesis and Activity of a New Series of Antileishmanial Agents. ACS MEDICINAL CHEMISTRY LETTERS, 8(8), 797-801. doi:10.1021/acsmedchemlett.7b00039


Giulianotti, M. A., Vesely, B. A., Azhari, A., Souza, A., LaVoi, T., Houghten, R. A., . . . Leahy, J. W. (2017). Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. ACS MEDICINAL CHEMISTRY LETTERS, 8(8), 802-807. doi:10.1021/acsmedchemlett.7b00045


Blake, L. D., Johnson, M. E., Siegel, S. V., McQueen, A., Iyamu, I. D., Shaikh, A. K., . . . Kyle, D. E. (2017). Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(8), 13 pages. doi:10.1128/AAC.00689-17


Wirjanata, G., Handayuni, I., Prayoga, P., Leonardo, L., Apriyanti, D., Trianty, L., . . . Marfurt, J. (2017). Plasmodium falciparum and Plasmodium vivax Demonstrate Contrasting Chloroquine Resistance Reversal Phenotypes. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(8), 10 pages. doi:10.1128/AAC.00355-17



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