Associate Professor Welcome to the Brain Neuron Research Lab! In our lab, we are passionate about uncovering the mysteries of the intricate network of neurons in the brain. Our main focus is to understand the critical roles of axons, dendrites and synapses, specialized components that are essential for the connections between neurons. We know that when these connections are disrupted, it can significantly impact brain function. Our primary goal is to investigate how cellular and molecular factors contribute to the formation and organization of these essential neuron connections. Additionally, we are curious about how these connections ensure proper brain function. By studying these factors, our lab aims to gain valuable insights into the causes of various neurological conditions. To conduct our cutting-edge studies, we use fruit flies and human cell cultures as model systems. These systems offer unique advantages, allowing us to employ genetic, biophysical, and biochemical approaches for in-depth analysis. Furthermore, we use innovative bioengineering techniques to explore the intricate molecular and cellular dynamics during brain formation and function. We invite you to join us on this exciting journey as we decode the secrets of the brain's connections. Together, we can contribute to shaping a better future for neurological research and healthcare, making a meaningful impact on the lives of many. Research Programs: Cells and Disease Cells in Development Cell Structure and Function Research Interests: Brain Development and Function in Health and Diseases Selected Publications Kamemura, K., Kozono, R., Okumura, M., Koga,D., Kusumi,S., Sekine,S., Kamiyama,D., and Chihara, T. Secretion of endoplasmic reticulum protein VAPB/ALS8 requires topological inversion. Nature Communications,15(1):8777.link Bui, KC., and Kamiyama, D. Adjacent Neuronal Fascicle Guides Motoneuron 24 Dendritic Branching and Axonal Routing Decisions through Dscam1 Signaling. eNeuro, 11(10):ENEURO.0130-24.link Bui, KC., and Kamiyama, D. CRISPR/Cas9-mediated knock-in in ebony gene using a PCR product donor template in Drosophila. Gene and Genome Editing 5, 100025. link Other Information Courses Regularly Taught: CBIO/BIOL 3400
